Impact of mechanical ventilation on severe acute kidney injury in critically ill patients with and without COVID-19 – a multicentre propensity matched analysis
Authors' conclusion
The analysis demonstrated that IMV as well as COVID-19 are associated with an increased risk for initiation of RRT.
Study context
- Population
- Critically ill ICU patients with and without COVID-19
- Participants
- 8,678 patients
- Exposure
- COVID-19 vs non-COVID-19 critically ill patients; Invasive mechanical ventilation (IMV) vs no IMV
- Outcome
- RRT initiation
Methodological detailspropensity matched, multicentre
- Propensity matched
- Multicentre
Main finding
As reported in the abstract
- Significantly lower probability of renal replacement therapy (RRT) initiation in COVID-19 patients in the first week of ICU stay (day 1)
- P < 0.0001
- Significantly lower probability of RRT initiation in COVID-19 patients in the first week of ICU stay (day 2)
- P = 0.021
Observational data: associations, not effects.
Further findings
Delay between IMV initiation and RRT
RRT initiation in mechanically ventilated patients · entire ICU stay
- Risk of RRT significantly higher with IMV; significantly increased in COVID-19 patients, non-significant trend in non-COVID-19 patients
ICU death in patients with RRT (IMV vs no IMV)
- Significantly higher risk of ICU death with IMV vs without IMV
Original publication
Impact of mechanical ventilation on severe acute kidney injury in critically ill patients with and without COVID-19 – a multicentre propensity matched analysis. Ann Intensive Care. Published 25 January 2025. doi:10.
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