Impact of mild hypo- and hyperventilation on cerebral oxygen supply during general anesthesia
An erratum to this article was published (Perioper Med (Lond), 30 Apr 2026 ↗)
Authors' conclusion
Even mild hypoventilation increased rSO2 compared to mild hyperventilation and this difference occurred independent of age.
Study context
- Population
- Patients under GA before the start of surgery
- Participants
- 78 participants
- Comparison
- YP vs OP
- Primary endpoint
- Difference in rSO2 (near-infrared spectroscopy (NIRS)) between hypo- and hyperventilation, compared between the two age groups
- Follow-up
- 15 min
Methodological detailsrandomised sequence, two age groups, Standardised anaesthetic management
- Randomised sequence
- Two age groups
- Standardised anaesthetic management
Primary result
As reported in the abstract
Δ rSO2 (hypo- vs hyperventilation)
YP
6
SD 3 · %
OP
6
SD 3 · %
P = 0.732
Further findings
rSO2, hypoventilation vs hyperventilation (YP) · 15 min
- rSO2 74 ± 4% after hypoventilation vs 68 ± 6% during hyperventilation (p < 0.001)
rSO2, hypoventilation vs hyperventilation (OP) · 15 min
- rSO2 71 ± 5% vs 65 ± 6% (p < 0.001)
Original publication
Impact of mild hypo- and hyperventilation on cerebral oxygen supply during general anesthesia. Perioper Med (Lond). Published 17 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →