Effects of low tidal volume on dynamic arterial elastance in patients undergoing laparoscopic surgery
Authors' conclusion
The reduction in tidal volume had a clinically negligible effect on Eadyn.
Study context
- Population
- Patients undergoing laparoscopic surgery with MAP < 65 mmHg and SVV > 10% after start of intra-abdominal insufflation
- Participants
- 46 patients
- Exposure
- Tidal volume 6 vs 8 mL/kg predicted body weight (PBW) (Eadyn); MAP responders vs non-responders to fluid challenge
- MAP respondersn = 35
- MAP non-respondersn = 11reference
- Outcome
- Effect of tidal volume reduction from 8 to 6 mL/kg PBW on dynamic arterial elastance (Eadyn)
Main finding
As reported in the abstract
Change in Eadyn after tidal volume reduction
Bland-Altman mean difference in Eadyn, before vs after tidal volume reduction
- 0.004
Bland-Altman 95% limits of agreement
- 0.285 to + 0.278
Observational data: associations, not effects.
Further findings
PPV and SVV change after tidal volume reduction
- PPV decrease
- - 19.4 ± 11%
- SVV decrease
- - 19.7 ± 9.9%
- Both decreased significantly; magnitude of decrease differed
Eadyn prediction of MAP responsiveness to fluid challenge
- AUC at 8 mL/kg PBW
- 0.514
- AUC at 6 mL/kg PBW
- 0.508
- Failed to predict MAP responsiveness
Original publication
Effects of low tidal volume on dynamic arterial elastance in patients undergoing laparoscopic surgery. J Clin Monit Comput. Published 9 October 2025. doi:10.
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