Impact of Nasal Staphylococcus aureus Carriage on Ventilator-Associated Pneumonia after Acute Brain Injury
Main finding · Occurrence of S. aureus VAPResult — go to the resultRelative risk 3.99 95% CI 1.70–9.53Authors' conclusion
Nasal carriage of S. aureus at ICU admission could be associated with the occurrence of S. aureus VAP and overall early VAP in brain-injured patients.
Study context
- Population
- Consecutive adults admitted to the Intensive Care Unit (ICU) with acute brain injury requiring invasive mechanical ventilation for at least 48 hourspatients included, 37 (38.5%) nasal carriers of S. aureus
- Participants
- Ninety-six adults
- Exposure
- Carriers vs non-carriers of nasal S. aureus at ICU admission
- Carriersn = 37
- Outcome
- Occurrence of S. aureus VAP
- Follow-up
- During ICU stay
Main finding
As reported in the abstract
Relative risk
3.99
95% CI 1.70–9.53
P = 0.001
By group
Carriers vs Non-carriers
RR 3.99 (95% CI 1.70–9.53); P = 0.001
Observational data: associations, not effects.
Secondary outcomes
Early VAP, regardless of pathogen · more frequent in carriers
45.9% vs. 18.6% · P = 0.02
Overall ventilator-associated pneumonia (VAP) (all patients)
- Patients who developed VAP
- 44 patients (45.8%)
Overall incidence of VAP and other secondary outcomes
- Did not differ significantly between groups
Original publication
Impact of Nasal Staphylococcus aureus Carriage on Ventilator-Associated Pneumonia after Acute Brain Injury. Anaesth Crit Care Pain Med. Published 2 October 2026. doi:10.
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