Respiratory failure & ventilation
Impact of positive end-expiratory pressure on renal resistive index in mechanical ventilated patients
Authors' conclusion
RRI seems able to predict the risk of AKI in mechanical ventilated patients; further, RRI values are influenced by the PEEP level applied.
Study context
- Population
- Critically ill patients requiring mechanical ventilation for ≥ 48 h
- Participants
- 92 patients
- Exposure
- Renal resistive index (RRI) at positive end-expiratory pressure (PEEP) 5, 10 and 15 cmH2O
- Outcome
- Prediction of AKI by RRI (measured within 24 h of ICU admission)
Methodological detailsPEEP levels applied in random order (PEEP trial)
- PEEP levels applied in random order (PEEP trial)
Main finding
As reported in the abstract
Prediction of AKI by mean RRI during the PEEP trial
AUROC of mean RRI for AKI
0.834
95% CI 0.742–0.927
AKI in patients with RRI ≥ 0.70 at least once (38 [41%]) vs remaining patients, p < 0.001
55% vs 13%
Observational data: associations, not effects.
Further findings
Pathological RRI (≥ 0.70)
| Outcome | PEEP 5 | PEEP 10 | PEEP 15 | P value |
|---|---|---|---|---|
| RRI by PEEP levelPEEP 15 vs PEEP 5 · RRI increased | 0.62 ± 0.09 | — not stated in the abstract | 0.66 ± 0.09 | P < 0.001 |
— not stated in the abstract
Original publication
Impact of positive end-expiratory pressure on renal resistive index in mechanical ventilated patients. J Clin Monit Comput. Published 21 May 2024. doi:10.
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