Perioperative medicine & outcomes
Impact of preoperative QTc interval prolongation on short-term postoperative outcomes: A retrospective study
Main finding · All-cause 90-day mortalityResult — go to the resultHazard ratio 3.124Authors' conclusion
Preoperative QTcI screening effectively risk-stratifies elderly surgical patients, with a QTcI≥500 ms being strongly predictive of short-term postoperative mortality and other complications.
Study context
- Population
- Patients aged ≥65 years undergoing noncardiac surgery, 2010–2023
- Participants
- 519,929 patients
- Exposure
- Preoperative QTcI prolongation categories vs control QTcI
- Outcome
- All-cause mortality
- Follow-up
- 90 days
Methodological detailspropensity-score matched, TriNetX network database
- Propensity-score matched
- TriNetX network database
Main finding
All-cause 90-day mortality
Hazard ratio
3.124
P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR | P value |
|---|---|---|
| New-onset AF · 90 daysLong vs Control | 3.059 | P < 0.001 |
| Ventricular arrhythmias · 90 daysLong vs Control | 3.617 | P < 0.001 |
| Emergency visits · 90 daysLong vs Control | 1.287 | P < 0.001 |
| Hospital readmissions · 90 daysLong vs Control | 1.591 | P < 0.001 |
| Pneumonia · 90 daysLong vs Control | 1.672 | P < 0.001 |
Ventricular arrhythmias · 90 days
- Dose-dependent response between QTcI and arrhythmia risk
Original publication
Impact of preoperative QTc interval prolongation on short-term postoperative outcomes: A retrospective study. J Clin Anesth. Published 8 August 2024. doi:10.
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