Perioperative medicine & outcomes
Preoperative Hemoglobin A 1C , Glycemic Status, and Postoperative Outcomes in General Surgery
Authors' conclusion
Dysglycemia-both diagnosed and undiagnosed-is highly prevalent among general surgery patients and independently associated with increased risks of complications, readmissions, or mortality.
Study context
- Population
- Adults (≥18 years) undergoing general surgery with available hemoglobin A1C (HbA1c) data, ACS NSQIP database 2021–2023
- Participants
- 282,131 adults
- Exposure
- Glycemic status categories vs normoglycemia
- Outcome
- Any, surgical and medical complications, readmissions, reoperations and mortality
- Follow-up
- 30 days after surgery
Methodological detailsmulticentre registry, multivariable logistic regression
- Multicentre registry
- Multivariable logistic regression
Main finding
As reported in the abstract
Any complication (diagnosed diabetes) · 30 days
Each group vs normoglycemiaOdds ratio (95% CI)
Diabetes, near normal
1.06(1.00–1.11)
Diabetes, very poor control
1.32(1.25–1.39)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Medical complications (undiagnosed diabetes) · 30 daysUndiagnosed diabetes vs Normoglycemia | 1.11 (1.04–1.18) | |
| Mortality (undiagnosed diabetes) · 30 daysUndiagnosed diabetes vs Normoglycemia | 1.24 (1.07–1.42) | |
| 0.512Odds ratio (log scale) |
Prevalence of glycemic status
- Diagnosed diabetes
- 36%
- HbA1c in diabetes range but no diagnosis
- 6.4%
Original publication
Preoperative Hemoglobin A 1C , Glycemic Status, and Postoperative Outcomes in General Surgery. JAMA Surg. Published 1 January 2026. doi:10.
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