Impact of Short-Acting Beta-Blockers on the Outcomes of Patients With Septic Shock: A Systematic Review and Meta-Analysis
Pooled result · 28-day mortalityResult — go to the resultRelative risk 0.76 95% CI 0.62–0.93Authors' conclusion
In patients with septic shock, short-acting beta-blockers may improve survival and reduce new-onset tachyarrhythmias.
Study context
- Population
- Adults with septic shock
- Participants
- 1,170 adults · 12 randomized controlled trials (RCTs)
- Comparison
- Short-acting beta-blockers vs usual care
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Pooled result
As reported in the abstract
Relative risk
0.76
95% CI 0.62–0.93
Short-acting beta-blockers vs Usual care
RR 0.76 (95% CI 0.62–0.93)
Further pooled results
| Outcome | RR (95% CI) | |
|---|---|---|
| New-onset tachyarrhythmiasModerate certainty | 0.37 (0.18–0.78) | |
| 90-day mortality · very low certainty | 0.98 (0.73–1.31) | |
| 0.20.5125Relative risk (log scale) |
| Outcome | MD (d) (95% CI) | |
|---|---|---|
| Duration of vasopressorsLow certainty | 1.04 (0.37–1.72) | |
| ICU LOSVery low certainty | −0.75 (−3.43 to 1.93) | |
| Hospital LOSVery low certainty | 1.03 (−1.92 to 3.98) | |
| Duration of mechanical ventilationVery low certainty | −0.10 (−1.25 to 1.05) | |
| −4−2024Difference, d (linear scale) |
Safety
| Outcome | RR (95% CI) | |
|---|---|---|
| Bradycardia episodesVery low certainty | 3.14 (0.91–14.01) | |
| Hypotension episodesVery low certainty | 4.74 (1.62–14.01) | |
| 0.050.21520Relative risk (log scale) |
Original publication
Impact of Short-Acting Beta-Blockers on the Outcomes of Patients With Septic Shock: A Systematic Review and Meta-Analysis. Crit Care Med. Published 26 February 2025. doi:10.
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