Hemodynamics, fluids & transfusion
Impact of therapeutic hypothermia on cardiogenic shock outcomes: a systematic review and meta-analysis
Pooled result · All-cause mortalityResult — go to the resultOdds ratio 0.83 CI 0.54–1.26Authors' conclusion
In this meta-analysis, therapeutic hypothermia appeared safe but failed to show a significant reduction in all-cause mortality in patients with CS, albeit with very low certainty of evidence.
Study context
- Population
- Patients with cardiogenic shock (CS)
- Participants
- 695 patients · 7 studies
- Comparison
- Therapeutic hypothermia vs no hypothermia
- Outcome
- All-cause mortality
- Follow-up
- 30 days
Methodological detailsmeta-regression, trial sequential analysis
- Meta-regression
- Trial sequential analysis
Pooled result
As reported in the abstract
Odds ratio
0.83
CI 0.54–1.26
Hypothermia vs No hypothermia
OR 0.83 (CI 0.54–1.26)
Further pooled results
| Outcome | IRR (CI) | |
|---|---|---|
| All-cause mortality · longest available follow-up | 0.85 (0.72–1.01) | |
| 0.512Incidence rate ratio (log scale) |
Meta-regression
- Hypothermia may be less beneficial and riskier in AMI-CS; greater benefit with mechanical circulatory support
Trial sequential analysis
- Cumulative Z-curve crossed neither benefit nor futility boundary; evidence inconclusive and underpowered
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Impact of therapeutic hypothermia on cardiogenic shock outcomes: a systematic review and meta-analysis. Ann Intensive Care. Published 19 August 2025. doi:10.
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