Cardiac arrest & resuscitation
Impact of time-to-compression on out-of-hospital cardiac arrest survival outcomes: A national registry study
Main finding · Good neurological function, per minute of no-flow intervalResult — go to the resultAdjusted odds ratio 0.98 95% CI 0.97–0.98Authors' conclusion
We demonstrated that prolonged no-flow interval had a significant effect on lower odds of favorable neurological outcomes, with medical futility occurring when no-flow interval was >12 mins (>7.5 mins for witnessed arrest).
Study context
- Population
- All out-of-hospital cardiac arrests (OHCAs) in Singapore, 2012 to 2017OHCAs analysed
- Participants
- 12,771 ohcas
- Exposure
- No-flow interval and survival outcomes
- Outcome
- Survival with favorable cerebral performance (Glasgow-Pittsburgh Cerebral Performance Categories 1/2)
Methodological detailsnational registry
- National registry
Main finding
As reported in the abstract
Good neurological function, per minute of no-flow interval
Adjusted odds ratio
0.98
95% CI 0.97–0.98
No-flow interval (per minute)
aOR 0.98 (95% CI 0.97–0.98)
Per minute, as printed
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aOR (95% CI) | |
|---|---|---|
| Survival to hospital discharge/30th day, per minute of no-flow interval | 0.98 (0.98–0.99) | |
| 0.512Adjusted odds ratio (log scale) |
Futility threshold (1% survival line)
- No-flow interval cutoff, overall
- 12 mins
- NPV
- 99%
- Sensitivity
- 85%
- Specificity
- 42%
- No-flow interval cutoff, witnessed arrests
- 7.5 mins
Original publication
Impact of time-to-compression on out-of-hospital cardiac arrest survival outcomes: A national registry study. Resuscitation. Published 26 July 2023. doi:10.
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