Perioperative medicine & outcomes
Impact of Perioperative Immunonutrition on Postoperative Outcomes for Patients Undergoing Head and Neck or Gastrointestinal Cancer Surgeries: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors' conclusion
Nutritional intervention with perioperative immunonutrition in patients with HAN and GI cancers significantly reduced total postoperative complications and infectious complications.
Study context
- Population
- Adults with or without malnutrition undergoing elective surgery for head and neck (HAN) or gastrointestinal (GI) cancers
- Participants
- 4,825 adults · 48 studies
- Comparison
- Perioperative immunonutrition vs standard nutritional therapy
- Outcome
- Total postoperative and infectious complications (Clavien-Dindo grade ≥ II)
- Follow-up
- Within 30 days after surgery
Methodological detailsIncluded studies: 19 upper GI, 9 lower GI, 8 mixed, 12 HAN cancer
- Included studies: 19 upper GI, 9 lower GI, 8 mixed, 12 HAN cancer
Pooled result
As reported in the abstract
Certainty of evidence: high
Each group vs standard nutritional therapyEstimate (95% CI)
Immunonutrition
RR (total postoperative complications) 0.78(0.66–0.93)
Immunonutrition
RR (infectious complications) 0.71(0.61–0.82)
Original publication
Impact of Perioperative Immunonutrition on Postoperative Outcomes for Patients Undergoing Head and Neck or Gastrointestinal Cancer Surgeries: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Ann Surg. Published 26 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →