Perioperative medicine & outcomes
Measurements of intestinal fatty acid binding protein (I-FABP) and citrulline in the postoperative period of non-cardiac surgeries with gastrointestinal complications: A prospective cohort observational study
Authors' conclusion
Urinary I-FABP and citrulline levels are promising diagnostic and prognostic markers in ICU patients following non-cardiac surgeries.
Study context
- Population
- Patients admitted to ICU after non-cardiac surgery
- Exposure
- Acute Gastrointestinal Injury (AGI) vs No AGI
- Outcome
- Diagnostic accuracy of citrulline and I-FABP for early AGI diagnosis and outcome prediction
Methodological detailsobservational
- Observational
Main finding
As reported in the abstract
AGI diagnosis by urinary I-FABP
AUC, urinary I-FABP day 3 (reasonable accuracy)
0.732
AUC, urinary I-FABP day 7 (good accuracy)
0.813
Observational data: associations, not effects.
Further findings
ICU mortality
P = 0.001
Hospital mortality
P = 0.003
AGI incidence
- AGI identified, with varying severity
- 40.3%
Sepsis prediction
- Urinary I-FABP on days 2 and 3 accurately predict sepsis
Mortality prediction
- AUC, urinary citrulline day 1
- 0.87
- Sensitivity, urinary I-FABP day 2 (reasonable accuracy)
- 83.3%
- Specificity, urinary I-FABP day 2
- 92.4%
Original publication
Measurements of I-FABP and citrulline in the postoperative period of non-cardiac surgeries with gastrointestinal complications: A prospective cohort observational study. J Crit Care. Published 9 February 2024. doi:10.
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