Perioperative medicine & outcomes
Impact of preoperative sleep disturbance on perioperative neurocognitive disorders in older adults undergoing major non-cardiac surgery: A multicenter prospective cohort study
Authors' conclusion
Untreated preoperative SD independently predicts both early delirium and POCD after major non-cardiac surgery.
Study context
- Population
- Patients aged ≥60 years undergoing major non-cardiac surgery (≥2 h)
- Participants
- 535 patients
- Exposure
- Preoperative sleep disturbance vs no sleep disturbance
- SDn = 288
- non-SDn = 247reference
- Outcome
- POCD
- Follow-up
- POD 7, 30, 90 and 180
Methodological detailsmulticentre, June 30, 2024 to May 31, 2025
- Multicentre
- June 30, 2024 to May 31, 2025
Main finding
As reported in the abstract
SD vs non-SDRelative risk (95 % CI)P value
Day 7: 41.7 % vs. 27.1 %
1.44(1.16–1.79)
P < 0.001Day 30: 36.1 % vs. 18.2 %
1.73(1.33–2.25)
P < 0.001Day 90: 25.7 % vs. 13.0 %
1.66(1.22–2.25)
P < 0.001Day 180: 19.4 % vs. 8.9 %
1.75(1.21–2.52)
P < 0.001Observational data: associations, not effects.
Secondary outcomes
Postoperative delirium · days 1-3
RR 1.43 · P = 0.006
Persistent insomnia · day 180
P < 0.001
| Outcome | Difference | P value |
|---|---|---|
| QoR-15 scoresPoorer in SD | 8 | P < 0.001 |
Pittsburgh Sleep Quality Index (PSQI)≥10 for predicting postoperative cognitive dysfunction (POCD)
%
- Sensitivity
- 71.8
- Specificity
- 69.4
- Optimal cut-off
Original publication
Impact of preoperative sleep disturbance on perioperative neurocognitive disorders in older adults undergoing major non-cardiac surgery: A multicenter prospective cohort study. J Clin Anesth. Published 7 January 2026. doi:10.
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