Perioperative medicine & outcomes
Associations of preoperative sleep disturbance with intraoperative and postoperative adverse outcomes among Chinese surgical patients: evidence from the China surgery and anesthesia cohort (CSAC)
Authors' conclusion
Preoperative sleep disturbance was significantly associated with multiple adverse outcomes.
Study context
- Population
- Chinese surgical patients aged 40–65 years at four medical centres, China Surgery and Anesthesia Cohort (CSAC), July 2020–November 202358.8 % female
- Participants
- 14,129 patients
- Exposure
- Preoperative sleep disturbance vs no sleep disturbance
- Outcome
- Two intraoperative, nine within-hospital and eight after-discharge adverse outcomes
Methodological detailsmulticentre, mediation analysis, k-means clustering
- Multicentre
- Mediation analysis
- K-means clustering
Main finding
As reported in the abstract
Adverse outcomes, sleep disturbance vs no sleep disturbance
- Associated with two within-hospital adverse outcomes (ORs)
- 1.19-1.52
- Postoperative moderate-to-severe sleep disturbance, ORs at 1 month
- 3.88-18.64
- Postoperative moderate-to-severe sleep disturbance, ORs at 6 months
- 3.44-13.31
- Postoperative moderate-to-severe sleep disturbance, ORs at 12 months
- 3.98-15.58
- Depression, ORs at 1 month
- 1.88-3.30
- Depression, ORs at 6 months
- 2.20-3.96
- Depression, ORs at 12 months
- 2.44-5.60
Observational data: associations, not effects.
Further findings
Preoperative sleep patterns (k-means clusters)
- 'Multiple sleep problems with daytime dysfunction' vs 'least affected': highest estimates for most adversities
Mediation analyses
- Postoperative moderate-to-severe sleep disturbance and depression significant mediators of longer-term adverse outcomes
Original publication
Associations of preoperative sleep disturbance with intraoperative and postoperative adverse outcomes among Chinese surgical patients: evidence from the China surgery and anesthesia cohort (CSAC). J Clin Anesth. Published 8 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →