Cardiothoracic & vascular anesthesia
The Impact of Prothrombin Complex Concentrate Versus Fresh Frozen Plasma for Hemorrhage Management in Cardiac Surgery: A Systematic Review and Meta-analysis of Randomized Clinical Trials
Pooled resultResult — go to the resultMean difference 1.17 g/dL 95% CI 0.93–1.41Authors' conclusion
In patients undergoing cardiac surgery with significant bleeding, PCC was associated with higher postintervention hemoglobin levels and reduced transfusion needs compared with FFP, without an increase in adverse events.
Study context
- Population
- Adults with hemorrhage related to coagulation factor deficiency during cardiac surgery
- Participants
- 671 adults · 4 randomized clinical trials (RCTs)
- Comparison
- Prothrombin complex concentrate (PCC) vs fresh frozen plasma (FFP) for hemorrhage management in cardiac surgery
- PCCn = 343
- Outcome
- Postintervention hemoglobin levels
Pooled result
As reported in the abstract
Mean difference
1.17 g/dL
95% CI 0.93–1.41
P < 0.01
PCC vs FFP
mean difference 1.17 g/dL (95% CI 0.93–1.41); P < 0.01
Further pooled results
RBC transfusions · 24 hours
- Fewer RBC transfusions with PCC vs FFP
Use of recombinant factor VII
- Reduced use with PCC vs FFP
Postintervention international normalized ratio
- Improved with PCC vs FFP
Original publication
The Impact of Prothrombin Complex Concentrate Versus Fresh Frozen Plasma for Hemorrhage Management in Cardiac Surgery: A Systematic Review and Meta-analysis of Randomized Clinical Trials. J Cardiothorac Vasc Anesth. Published 6 September 2025. doi:10.
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