Perioperative medicine & outcomes
Impact of ventilation strategies on pulmonary and cardiovascular complications in patients undergoing general anaesthesia for elective surgery: a systematic review and meta-analysis
Authors' conclusion
Optimal intraoperative mechanical ventilation is unclear; however, our meta-analysis showed that low tidal volume and driving pressure-guided PEEP strategies were associated with a reduction in postoperative pulmonary complications.
Study context
- Population
- Adults undergoing GA for elective surgery
- Participants
- 4,993 adults · 16 RCTs
- Comparison
- Low vs high tidal volume; higher vs lower PEEP; driving pressure-guided vs fixed PEEP
- Outcome
- Incidence of postoperative pulmonary complications
Pooled result
As reported in the abstract
Odds ratio (CI)P value
LV vs HV
0.402(0.280–0.577)
P < 0.001DP vs FP
0.358(0.187–0.684)
P = 0.002Further pooled results
30-day mortality
- Not influenced by the ventilation strategy
Safety
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| Intraoperative cardiovascular complicationsHP vs LP | 1.385 (1.027–1.867) | P = 0.002 | |
| 0.512Odds ratio (log scale) |
Original publication
Impact of ventilation strategies on pulmonary and cardiovascular complications in patients undergoing general anaesthesia for elective surgery: a systematic review and meta-analysis. Br J Anaesth. Published 14 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →