The implementation of intrathecal morphine for caesarean delivery into clinical practice, and assessment of its impact on patient-reported quality of recovery using the ObsQoR-10-Dutch scale: A single-centre cohort study
Main finding · ObsQoR-10-Dutch score (0 to 100)Result — go to the resultMean difference 9.0 points 95% CI 3.1–15Authors' conclusion
Implementing ITM for caesarean delivery resulted in moderate improvements in obstetric recovery and reduced opioid consumption.
Study context
- Population
- Patients undergoing caesarean delivery under spinal anaesthesia, tertiary university hospital, the Netherlands, January 2023 to April 2024
- Participants
- 55 vs 47
- Exposure
- Intrathecal morphine (ITM) vs pre-ITM analgesia
- pre-ITMn = 55reference
- ITMn = 47
- Outcome
- ObsQoR-10-Dutch score (0 to 100)
Methodological detailssingle-centre, Protocol adherence for ITM was 98%
- Single-centre
- Protocol adherence for ITM was 98%
Main finding
As reported in the abstract
Mean difference
9.0 points
95% CI 3.1–15
P = 0.002
By group
ITM vs pre-ITM
mean difference 9.0 points (95% CI 3.1–15); P = 0.002
- Improvement in multivariate analysis, 95% CI 0.37 to 12.2 points; statistically significant but below the predefined threshold for clinical relevance
- 6.3
Observational data: associations, not effects.
Secondary outcomes
Self-reported general health score (0 to 100), pre-ITM vs ITM
- pre-ITM vs ITM (mean ± SD)
- 57 ± 18 vs. 68 ± 17
- P = 0.002
Length of hospital stay, pre-ITM vs ITM
- pre-ITM vs ITM, median [IQR], h
- 41 [36 to 51] vs. 37 [32 to 49]
- P = 0.032
Opioid consumption, pre-ITM vs ITM
- pre-ITM vs ITM, median [IQR], mg
- 52 [35 to 73] vs. 0 [0 to 0]
- P < 0.001
ObsQoR-10 subscores
- Improvement in pain scores, physical comfort, independence and psychological wellbeing
Original publication
The implementation of intrathecal morphine for caesarean delivery into clinical practice, and assessment of its impact on patient-reported quality of recovery using the ObsQoR-10-Dutch scale: A single-centre cohort study. Eur J Anaesthesiol. Published 29 January 2025. doi:10.
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