Implementation of a Prevention Bundle to Decrease Rates of Staphylococcus aureus Surgical Site Infection at 11 Veterans Affairs Hospitals
Authors' conclusion
Although this quality improvement study suggests an association between implementation of an SSI prevention bundle and decreased S aureus deep incisional or organ space SSI rates after TJAs, it was underpowered to see a significant difference when accounting for changes over time.
Study context
- Population
- Patients undergoing CABG, cardiac valve replacement or total joint arthroplasty (TJA) at 11 Veterans Administration hospitals, 2007–20186,696 cardiac procedures · 16,309 TJAs
- Comparison
- Postintervention vs preintervention period
- Outcome
- Deep incisional or organ space SSI caused by S aureus
Methodological detailspreintervention vs postintervention, interrupted time-series, multicentre, Rolling implementation April 2012 to July 2017; data January 2007 to March 2018
- Preintervention vs postintervention
- Interrupted time-series
- Multicentre
- Rolling implementation April 2012 to July 2017; data January 2007 to March 2018
Main finding
As reported in the abstract
S aureus deep incisional or organ space SSI after TJAs
InterventionEstimate (95% CI)
GEE model; significant association with decreased SSI rates
aOR 0.55(0.31–0.98)
ITS model; not significant
adjusted IRR 0.88(0.32–2.39)
Further findings
S aureus deep incisional or organ space surgical site infection (SSI) after cardiac operations
- No significant associations after cardiac operations
Original publication
Implementation of a Prevention Bundle to Decrease Rates of Staphylococcus aureus Surgical Site Infection at 11 Veterans Affairs Hospitals. JAMA Netw Open. Published 3 July 2023. doi:10.
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