Improvement of composite kidney outcomes by acute kidney injury (AKI) care bundles: a systematic review and meta-analysis
Pooled result · MAKEResult — go to the resultOdds ratio 0.73 95% CI 0.66–0.81Authors' conclusion
Our meta-analysis demonstrated that care bundles decreased the risk of MAKE, moderate-severe AKI and need for RRT in AKI patients.
Study context
- Population
- Patients at risk of or with AKI13 studies (5 randomized controlled trials (RCTs), 8 non-RCTs)
- Participants
- 16,540 patients
- Comparison
- AKI care bundles vs usual care
- Outcome
- MAKE (moderate-severe AKI, receipt of RRT, and mortality)
Methodological detailsnetwork meta-analysis
- Network meta-analysis
Pooled result
MAKE
Odds ratio
0.73
95% CI 0.66–0.81
AKI care bundle vs Usual care
OR 0.73 (95% CI 0.66–0.81)
As reported in the abstract
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| Moderate-severe AKI | 0.65 (0.51–0.82) | |
| RRT | 0.63 (0.46–0.88) | |
| MAKE, RCTs only (subgroup; all biomarker-based) | 0.55 (0.41–0.74) | |
| MAKE, network meta-analysisCare bundles with biomarkers vs Care bundles without biomarkers | 0.693 (0.50–0.96) | |
| 0.512Odds ratio (log scale) |
MAKE, network meta-analysis
| OR (95% CI) | ||
|---|---|---|
| Usual careSignificantly higher risk | 1.29 (1.09–1.52) | |
| 0.512Odds ratio (log scale) |
Mortality
- Difference in mortality with AKI care bundle
Original publication
Improvement of composite kidney outcomes by AKI care bundles: a systematic review and meta-analysis. Crit Care. Published 9 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →