ICU sedation, delirium & recovery
Intensive Care Platform Trial (INCEPT): The Intensive Care Platform Trial—Design and protocol
Study context
- Population
- Adults acutely admitted to intensive care unit (ICUs)
- Planned comparison
- Comparable groups of commonly used ICU interventions nested in domains
- Primary endpoint
- Each domain will use one of these core outcomes as the primary outcome
Methodological detailsinvestigator-initiated, pragmatic, embedded, multifactorial, international, Bayesian, response-adaptive randomisation, Interventions open-label or masked; new domains continuously added, Bayesian analysis with neutral, minimally informative or sceptical priors, adjusted for prognostic baseline variables, ITT populations, Domains and arms may stop for superiority/inferiority, practical equivalence or futility per pre-specified adaptation rules or at maximum sample sizes
- Investigator-initiated
- Pragmatic
- Embedded
- Multifactorial
- International
- Bayesian
- Response-adaptive randomisation
- Interventions open-label or masked; new domains continuously added
- Bayesian analysis with neutral, minimally informative or sceptical priors, adjusted for prognostic baseline variables, ITT populations
- Domains and arms may stop for superiority/inferiority, practical equivalence or futility per pre-specified adaptation rules or at maximum sample sizes
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
INCEPT: The Intensive Care Platform Trial—Design and protocol. Acta Anaesthesiol Scand. Published 14 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →