ICU sedation, delirium & recovery

Incidence and onset of central venous catheter-related thrombosis in critically ill surgical patients: A prospective observational single-center study

J Clin AnesthPublished Prospective observational study

Authors' conclusion

Almost all CVCs in the internal jugular vein in critically ill surgical patients developed an asymptomatic CRT in the first days after catheterization.

Study context

Population
Critically ill patients with CVCs (surgical 79.8%/medical 20.2%) in a university hospital surgical ICU over six months
Participants
94 first-time internal jugular CVCs
Exposure
Types of CVC
Outcome
Time of onset of CRT, depending on the type of CVC (3 to 5 lumens, 3 different manufacturers)
Methodological detailsinvestigator-initiated, single-centre
  • Investigator-initiated
  • Single-centre

Main finding

As reported in the abstract

Time to CRT
Median time to catheter-related thrombosis (CRT) across CVC types (days)
one to five
CVCs with CRT within one day
37 to 64%
CVCs with CRT within one week
64 to 100%

Observational data: associations, not effects.

Further findings

CRT risk factors (multiple Cox regression)

Cancer, omitting prophylactic anticoagulation and some CVC types associated with higher CRT risk

Safety

Symptomatic CRT and complications

All but one CRT asymptomatic; no complications

Original publication

Incidence and onset of central venous catheter-related thrombosis in critically ill surgical patients: A prospective observational single-center study. J Clin Anesth. Published 24 July 2024. doi:10.1016/j.jclinane.2024.111556

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