Pediatric anesthesia & critical care
Incidence of High Severity Anesthesia Related Adverse Events With Increasing PREDIC 3 T Risk Category in Congenital Cardiac Catheterization: A Review of the Catheterization Project on Outcomes (C3PO) Database
Authors' conclusion
The overall rate of ARAE, including high severity ARAE, was found to be increased in higher PREDIC3T risk category procedures.
Study context
- Population
- Pediatric patients with congenital heart disease undergoing cardiac catheterization, C3PO database, 18 institutions, 2019–2023
- Participants
- 38, 021 cardiac catheterizations
- Exposure
- High severity anesthesia related adverse events (ARAE) rates across PREDIC3T case-type risk categories, lowest (zero) to highest (5)
- Outcome
- High severity anesthesia related adverse events (ARAE, level 3bc/4/5) by PREDIC3T risk category
Methodological detailsmulticentre, prospectively collected registry data
- Multicentre
- Prospectively collected registry data
Main finding
As reported in the abstract
High severity ARAE (level 3bc/4/5) by PREDIC3T risk category
PREDIC3T zero
0.2%
- Overall high severity ARAE
- 0.4%
Observational data: associations, not effects.
Further findings
ARAE of any severity (level 1-5)
- Overall ARAE of any severity
- 321 (0.8%; CI, 0.7%-0.9%)
Factors associated with high severity ARAE (multivariable logistic regression)
- Weight under 10 kg, hemodynamic vulnerability score (HVS) ≥ 1 and PREDIC3T risk category 5 procedures associated with higher odds of high severity ARAE
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Incidence of High Severity Anesthesia Related Adverse Events With Increasing PREDIC 3 T Risk Category in Congenital Cardiac Catheterization: A Review of the C3PO Database. Paediatr Anaesth. Published 31 December 2025. doi:10.
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