Incidence, Mortality, and Long‐Term Survival in Patients With Acute Pancreatitis Admitted to Intensive Care: A Nationwide Cohort Study
Authors' conclusion
Admissions to the ICU for AP seem to increase in a national cohort, and 90-day mortality occurred in almost every 1 of 4 patients. Patients with ICU-treated AP discharged alive from the hospital have good long-term survival, although with reduced longevity compared to the age- and gender-adjusted general population.
Study context
- Population
- Adults with acute pancreatitis admitted to Norwegian intensive care units (ICUs), 2016–2021
- Participants
- 1,183 adults
- Outcome
- Incidence over time and predictors of 90-day mortality
- Follow-up
- 90 days
Methodological detailsregistry-based
- Registry-based
Main finding
As reported in the abstract
Average annual incidence per 100,000 inhabitants (increased, ptrend = 0.048)
3.8
In-hospital mortality (n = 243)
20.5%
90-day mortality (n = 270)
22.8%
1-year cumulative mortality (n = 331)
28.0%
Observational data: associations, not effects.
Further findings
Independent predictors of 90-day mortality
| OR (95% CI) | ||
|---|---|---|
| Age | 1.05 (1.04–1.07) | |
| SAPS II score | 1.06 (1.05–1.07) | |
| Charlson Comorbidity Index score | 1.2 (1.10–1.31) | |
| 0.512Odds ratio (log scale) |
Risk of death in hospital survivors (multivariable survival analysis)
| HR (95% CI) | ||
|---|---|---|
| Age | 1.05 (1.04–1.07) | |
| SAPS II | 1.01 (1.00–1.02) | |
| CCI | 1.29 (1.21–1.38) | |
| Biliary etiology | 0.48 (0.30–0.78) | |
| Longer ICU LOS | 0.98 (0.97–1.00) | |
| 0.20.5125Hazard ratio (log scale) |
Independent predictors of 90-day mortality
- Pancreatitis etiology also an independent predictor
Risk of death in hospital survivors (multivariable survival analysis)
- No association between advanced organ support and death after hospital discharge
Long-term survival of patients discharged alive vs age- and gender-matched population
- Relative long-term survival approximately
- 90%
Original publication
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