Perioperative medicine & outcomes
Incidence of acute kidney injury after noncardiac surgery in patients receiving intraoperative dexmedetomidine: a retrospective study
Authors' conclusion
The administration of dexmedetomidine during major non-cardiothoracic cancer surgery is not associated with a reduction in AKI within 72 h after surgery.
Study context
- Population
- Patients undergoing major non-cardiothoracic cancer surgery
- Participants
- 6,625 patients
- Exposure
- Intraoperative dexmedetomidine vs no dexmedetomidine
- Dexmedetomidinen = 1,301
- Outcome
- Postoperative acute kidney injury (AKI) (KDIGO creatinine-alone criteria)
- Follow-up
- Postoperative Days 1, 2, and 3
Methodological detailspropensity score matched
- Propensity score matched
Main finding
As reported in the abstract
Incidence of AKI
P = 0.333
Observational data: associations, not effects.
Further findings
Anaesthesia duration
- Longer anaesthesia duration with dexmedetomidine vs non-dexmedetomidine
30-day mortality
- Not statistically different between the groups
Safety
Infection, cardiovascular complications, reoperation attributable to bleeding · 30 day
- Higher rates in patients treated with dexmedetomidine
Original publication
Incidence of acute kidney injury after noncardiac surgery in patients receiving intraoperative dexmedetomidine: a retrospective study. BJA Open. Published 9 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →