Pediatric anesthesia & critical care
Incidence of and risk factors for paediatric perioperative anaphylaxis in the USA
Authors' conclusion
The incidence of pPOA was one in 12,125 cases. Risk factors included age, procedure type, and comorbidities.
Study context
- Population
- Children aged 0–18 yr undergoing surgeries and procedures, US Nationwide Inpatient Sample 2005–2014surgeries and procedures
- Participants
- 3,601,180 children
- Exposure
- Paediatric perioperative anaphylaxis (pPOA) cases vs controls
- pPOA casesn = 297
- Outcome
- Incidence of paediatric perioperative anaphylaxis (pPOA)
Methodological detailsnational database, multivariate analysis
- National database
- Multivariate analysis
Main finding
As reported in the abstract
Incidence of pPOA
pPOA cases
one in 12,125 surgeries and procedures
297 of 297
Observational data: associations, not effects.
Further findings
LOS
P < 0.001
Risk factors for pPOA: age
| OR (95% CI) | P value | ||
|---|---|---|---|
| Age 6–12 yr | 7.1 (3.9–12.9) | P < 0.001 | |
| Age 13–17 yr | 8.5 (4.7–15.2) | P < 0.001 | |
| 0.050.21520Odds ratio (log scale) |
Risk factors for pPOA: procedure type
| OR (95% CI) | P value | ||
|---|---|---|---|
| Transplant | 46.3 (20.8–102.9) | P < 0.001 | |
| Cardiac | 16.4 (7.5–35.9) | P < 0.001 | |
| Vascular | 15.2 (7.5–30.7) | P < 0.001 | |
| 0.050.21520Odds ratio (log scale) |
Risk factors for pPOA: comorbidities
| OR (95% CI) | P value | ||
|---|---|---|---|
| Chronic pulmonary disease, coagulopathy, fluid and electrolyte disorders | 2.2 (1.5–3.3) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | pPOA cases | Controls | P value |
|---|---|---|---|
| Hospital cost | median $54 719 | median $5109 | P < 0.0001 |
Original publication
Incidence of and risk factors for paediatric perioperative anaphylaxis in the USA. Br J Anaesth. Published 3 July 2024. doi:10.
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