Incidence of persistent postoperative opioid use in patients undergoing ambulatory surgery: a retrospective cohort study
Authors' conclusion
More than 10% of patients who underwent ambulatory surgery experienced persistent postoperative opioid use; however, there was a temporal trend towards a reduction in persistent opioid use after surgery.
Study context
- Population
- Adults undergoing ambulatory surgery in Ontario, Canada, 1 January 2013 to 31 December 2017
- Participants
- 340,013 adults
- Outcome
- Persistent postoperative opioid use (best-practice definition)
Methodological detailspopulation-based, routinely collected administrative data
- Population-based
- Routinely collected administrative data
Main finding
As reported in the abstract
Persistent postoperative opioid use
Incidence of persistent postoperative opioid use: 44,224 patients, 95% CI 12.9-13.1%
13.0%
Observational data: associations, not effects.
Further findings
Predictors of persistent postoperative opioid use (multivariable adjustment)
| OR (95% CI) | ||
|---|---|---|
| Pre-operative opioid utilisationStrongest predictors were pre-operative | 9.51 (8.69–10.39) | |
| Pre-operative opioid toleranceStrongest predictors were pre-operative | 88.22 (77.21–100.79) | |
| Pre-operative utilisation of benzodiazepinesStrongest predictors were pre-operative | 13.75 (12.89–14.86) | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | Adjusted percentage change per year (95% CI) | P value | |
|---|---|---|---|
| Temporal trend in persistent postoperative opioid use (time series model)Small but significant trend towards decreasing use | −0.51% (−0.83 to −0.19%) | P = 0.003 | |
| −1−0.500.5Difference (linear scale) |
Original publication
Incidence of persistent postoperative opioid use in patients undergoing ambulatory surgery: a retrospective cohort study. Anaesthesia. Published 31 October 2022. doi:10.
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