Increased Global and Regional Connectivity in Propofol-induced Unconsciousness: Human Intracranial Electroencephalography Study
Authors' conclusion
Propofol anesthesia suppresses cortical activity and induces oscillatory changes characterized by increased delta power and decreased high gamma power. These changes are accompanied by increased functional connectivity and reduced network complexity and efficiency.
Study context
- Population
- Patients with intracranial EEG recordings undergoing propofol-induced unconsciousness
- Participants
- 73 patients
- Comparison
- Propofol-induced unconsciousness vs conscious state
- Outcome
- Global and regional changes in amplitude- and phase-based functional connectivity
Methodological detailshuman intracranial EEG, machine learning analysis
- Human intracranial EEG
- Machine learning analysis
Main finding
As reported in the abstract
- Global connectivity increased across all frequency bands in the unconscious state
- Global complexity and efficiency decreased
- Increased delta and decreased high gamma power spectral density
- Regional connectivity increased between entire cortical regions across all frequency bands
- Posterior connectivity most influential in classifying consciousness (machine learning)
- Amplitude-based connectivity increased predominantly in delta and theta bands; phase-based connectivity predominantly from beta to high gamma bands
Original publication
Increased Global and Regional Connectivity in Propofol-induced Unconsciousness: Human Intracranial Electroencephalography Study. Anesthesiology. Published 3 April 2025. doi:10.
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