Changes in Intra- and Cross-hemispheric Directed Functional Connectivity in the Electroencephalographic Signals during Propofol-induced Loss of Consciousness
Authors' conclusion
Propofol-induced loss of consciousness in surgical patients is associated with a global breakdown in low-frequency directed functional connectivity, coupled with a high-frequency increase between closely located brain regions. At loss of consciousness, Granger causality shows more pronounced changes than coherence.
Study context
- Population
- Adult male surgical patients undergoing propofol-induced loss of consciousness during induction of anesthesia
- Participants
- 29 patients
- Comparison
- EEG functional connectivity before vs after propofol-induced loss of consciousness
- Outcome
- Frontal and frontoparietal directed (frequency domain Granger causality) and undirected (EEG coherence) functional connectivity
- Follow-up
- Around loss of consciousness
Main finding
As reported in the abstract
Granger causality across EEG frequency bands
- Local frontal, interhemispheric frontal and frontoparietal feedback and feedforward Granger causality decreased in the delta band
- between 31% and 51.5%
- Local frontal delta Granger causality, median [IQR]
- 0.14 [0.08, 0.27] to 0.08 [0.06, 0.12]; P = 0.02
- Local frontal Granger causality in gamma and beta bands increased after a lag of a few minutes, median [IQR]
- 0.03 [0.02, 0.07] to 0.09 [0.07, 0.11]; P < 0.001
- Long-distance cross-hemispheric frontoparietal feedback Granger causality increased, median [IQR]
- 0.02 [0.01, 0.04] to 0.07 [0.04, 0.09]; P < 0.001
- Long-distance cross-hemispheric frontoparietal feedforward Granger causality increased, median [IQR]
- 0.02 [0.01, 0.04] to 0.03 [0.03, 0.04]; P = 0.01
Original publication
Changes in Intra- and Cross-hemispheric Directed Functional Connectivity in the Electroencephalographic Signals during Propofol-induced Loss of Consciousness. Anesthesiology. Published 23 September 2024. doi:10.
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