Electroencephalographic changes related to cortico-subcortical decoupling during propofol-induced loss of consciousness: A secondary analysis of a prospective observational study
Authors' conclusion
Cortico-subcortical decoupling related to propofol-induced LOC coincides with a gradual decrease in the qCON index and an increase in frontal alpha power.
Study context
- Population
- Healthy volunteers receiving a targeted propofol infusion, tertiary-care hospital, June 2017 to January 201916 analysed
- Participants
- 19 volunteers
- Comparison
- Before vs after cortico-subcortical decoupling at propofol-induced loss of consciousness (LOC)
- Primary endpoint
- The qCON index and frontal EEG before and after decoupling at LOC
Primary result
As reported in the abstract
qCON index and frontal alpha band power
Before decoupling
0.07
median · IQR 0.03–0.15
After decoupling
0.48
median · IQR 0.08–0.58
P < 0.001
Further findings
Propofol concentration at LOC
- Target plasma concentration, median (IQR) 4.5 (3.91 to 4.61) μg/mL
- Effect-site concentration, median (IQR) 4.0 (2.94 to 4.31) μg/mL
Original publication
Electroencephalographic changes related to cortico-subcortical decoupling during propofol-induced loss of consciousness: A secondary analysis of a prospective observational study. J Clin Anesth. Published 17 July 2025. doi:10.
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