Changes in Intrinsic Connectivity Networks Topology Across Levels of Dexmedetomidine-Induced Alteration of Consciousness
Authors' conclusion
The differential dexmedetomidine-induced RSN topological changes evidenced in this study may be the signature of inadequate processing of sensory information by lower-order RSNs, and of altered communication between lower-order and higher-order networks, while the latter remain functional.
Study context
- Population
- Healthy volunteers receiving dexmedetomidine sedation
- Participants
- 14 healthy volunteers
- Comparison
- 4 steady-state levels of dexmedetomidine-induced alteration of consciousness: Awake, Mild sedation, Deep sedation, Recovery
- Outcome
- Changes in RSN connectivity strength and efficiency (graph theory)
Methodological detailsfunctional MRI, independent component analysis and graph theory
- Functional MRI
- Independent component analysis and graph theory
Main finding
As reported in the abstract
- Dexmedetomidine sedation preserves RSN architecture
- Unresponsiveness: between-networks graph strength alteration and within-network efficiency alteration of lower-order sensory RSNs
- Graph strength and efficiency in higher-order RSNs relatively preserved
Original publication
Changes in Intrinsic Connectivity Networks Topology Across Levels of Dexmedetomidine-Induced Alteration of Consciousness. Anesth Analg. Published 30 January 2024. doi:10.
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