Reframing "paradoxical" excitation: disentangling electroencephalogram complexity and entropy reveals resting-state dynamics associated with propofol susceptibility in healthy adults
Authors' conclusion
Baseline EEG complexity indexes individual sensitivity to propofol, determining whether brain dynamics transiently enter excitation or direct suppression.
Study context
- Population
- Healthy adults receiving propofoltwo cohorts
- Participants
- 20 vs 8
- Comparison
- Chennu dataset vs ReCCognition dataset
- Chennu datasetn = 20
- ReCCognition datasetn = 8
- Outcome
- EEG complexity (Lempel-Ziv, Type I; statistical complexity, Type II) on the CECP during propofol sedation
Methodological detailssecondary analysis of EEG data from two independent cohorts
- Secondary analysis of EEG data from two independent cohorts
Main finding
As reported in the abstract
Baseline statistical complexity vs change in statistical complexity (correlation r)
−0.88
Original publication
Reframing "paradoxical" excitation: disentangling electroencephalogram complexity and entropy reveals resting-state dynamics associated with propofol susceptibility in healthy adults. Br J Anaesth. Published 1 June 2026. doi:10.
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