Increasing protein dose does not further augment muscle protein synthesis in critical illness: a randomized, controlled clinical trial
Primary resultResult — go to the resultAdjusted mean difference 0.007 %·h-1 95% CI −0.003 to 0.016Authors' conclusion
Higher enteral protein does not further augment postprandial muscle protein synthesis rates to overcome -anabolic resistance during critical illness, despite increased plasma amino acid availability.
Study context
- Population
- Mechanically ventilated critically ill patients
- Participants
- 20 participants
- Comparison
- Single intraduodenal bolus of 40 g vs 20 g whey protein isolate
- 40 gn = 10
- 20 gn = 10reference
- Primary endpoint
- Postprandial muscle protein synthesis rates
- Follow-up
- 6 h postprandial period
Primary result
As reported in the abstract
Adjusted mean difference
0.007 %·h-1
95% CI −0.003 to 0.016
P = 0.152
By group
40 g vs 20 g
adjusted mean difference 0.007 %·h-1 (95% CI −0.003 to 0.016); P = 0.152
Further findings
Postprandial plasma leucine availability (AUC)
P = 0.005
Postprandial plasma tyrosine availability (AUC)
P = 0.006
| Outcome | 40 g | 20 g | P value |
|---|---|---|---|
| Fasting muscle protein synthesis rates | mean 0.020 (SD 0.012) %·h-1 | — not stated in the abstract | P = 0.558 |
— not stated in the abstract
Muscle protein synthesis rates, fasting to postprandial (post hoc uncontrolled analysis)
- Increased in the 40 g group only
- P = 0.005
- Post hoc uncontrolled analysis
Original publication
Increasing protein dose does not further augment muscle protein synthesis in critical illness: a randomized, controlled clinical trial. Am J Respir Crit Care Med. Published 24 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →