Incretins Predict Response to Enteral Nutrition Strategies in the EDEN Trial: A Secondary Analysis
Authors' conclusion
GIP was unique among incretins in predicting HTE to enteral nutrition strategies in EDEN.
Study context
- Population
- Acute respiratory distress syndrome (ARDS) patients in the EDEN trial with pre-intervention plasma samples
- Participants
- 889 patients
- Comparison
- Trophic vs full enteral nutrition, by baseline incretin levels
- Trophicn = 452
- Fulln = 437reference
- Primary endpoint
- 60-day mortality (HTE by interaction of treatment with circulating incretin levels)
- Follow-up
- 60 days
Methodological detailsbiomarker analysis of heterogeneity of treatment effect, adjusted interaction analysis
- Biomarker analysis of heterogeneity of treatment effect
- Adjusted interaction analysis
Primary result
As reported in the abstract
60-day mortality, highest GIP tertile
- GIP predicted heterogeneity of treatment effect (HTE) to enteral nutrition strategies (adjusted interaction p-value)
- 0.01
Further findings
- GLP-1, ARDS subphenotypes, and baseline risk of mortality did not predict HTE
Original publication
Incretins Predict Response to Enteral Nutrition Strategies in the EDEN Trial: A Secondary Analysis. Am J Respir Crit Care Med. Published 13 July 2026. doi:10.
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