Perioperative medicine & outcomes
Individual and combined effects of chemical and mechanical power on postoperative pulmonary complications: a secondary analysis of the REPEAT study
Authors' conclusion
Both chemical and mechanical power are independently associated with postoperative pulmonary complications.
Study context
- Population
- Patients in three RCTs of intra-operative ventilation3,837 recruited
- Participants
- 2,492 patients
- Comparison
- Per 1 J.min-1 increase in intra-operative chemical or mechanical power
- Primary endpoint
- Collapsed composite of PPCs
Methodological detailsindividual patient data analysis of three randomised clinical trials, multivariable logistic regression
- Individual patient data analysis of three randomised clinical trials
- Multivariable logistic regression
Primary result
As reported in the abstract
PPCs per 1 J.min-1 increase
Odds ratio (95% CI)P value
Chemical power (per 1 J.min-1)8% higher odds; adjusted
1.08(1.05–1.10)
P < 0.001Mechanical power (per 1 J.min-1)5% higher odds; adjusted
1.05(1.02–1.08)
P = 0.003Per 1 J.min-1, as printed
- No significant interaction between chemical and mechanical power (additive rather than synergistic)
- P = 0.40
Further findings
Intra-operative time-weighted average power
- Chemical power, mean (SD), J.min-1
- 10.2 (3.9)
- Mechanical power, mean (SD), J.min-1
- 10.5 (4.4)
Original publication
Individual and combined effects of chemical and mechanical power on postoperative pulmonary complications: a secondary analysis of the REPEAT study. Anaesthesia. Published 19 August 2025. doi:10.
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