Individual monocytic HLA-DR (mHLA-DR) trajectories in the ICU as predictors of early infections following liver transplantation: a prospective observational study
Authors' conclusion
Our findings highlight mHLA-DR as an early predictor of post-LT infections.
Study context
- Population
- Patients awaiting liver transplantation at Lyon University Hospital99 underwent liver transplantation (LT)
- Participants
- 130 patients
- Exposure
- Delayed vs non-delayed mHLA-DR recovery after liver transplantation
- Outcome
- Early post-LT infections
Methodological detailssingle-centre, multivariate analysis, K-means longitudinal clustering
- Single-centre
- Multivariate analysis
- K-means longitudinal clustering
Main finding
As reported in the abstract
Patients with early post-LT infections
35.4%
Delayed mHLA-DR recovery (Day 7 < 11,000 AB/C), independent infection risk factor: OR [4.4-38.2], p < 0.0001
12.1
Pre-LT MELD score > 30, independent infection risk factor: OR [1.4-18.4], p = 0.01
4.9
Observational data: associations, not effects.
Further findings
One-year survival, delayed vs non-delayed mHLA-DR restoration
- One-year survival, delayed mHLA-DR restoration (p = 0.003)
- 77.8%
- One-year survival, other patients (p = 0.003)
- 98.3%
mHLA-DR recovery profiles (K-means clustering)
- Three distinct mHLA-DR recovery profiles; slowest recovery group had the poorest outcomes
Original publication
Individual mHLA-DR trajectories in the ICU as predictors of early infections following liver transplantation: a prospective observational study. Crit Care. Published 18 February 2025. doi:10.
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