Prevention of Liver-related Surgical Site Infections in Combined Liver and Colorectal Surgery
Authors' conclusion
PPA is associated with a significant liver-SSI reduction following SLCR
Study context
- Population
- Patients undergoing simultaneous liver and colorectal resections (SLCR) for colorectal liver metastases, 2012–2024
- Participants
- 250 patients · 2 tertiary centres
- Exposure
- PPA vs IPA
- PPAn = 100
- Outcome
- Liver-specific surgical site infection (liver-SSI) incidence
Methodological detailstwo tertiary centres, propensity-score matched, inverse probability treatment weighting, mixed-effects models
- Two tertiary centres
- Propensity-score matched
- Inverse probability treatment weighting
- Mixed-effects models
Main finding
As reported in the abstract
Liver-SSI
PPA vs IPAOdds ratio (95% CI)P value
Before matching
0.24(0.09–0.57)
P = 0.002After PSM
0.27(0.09–0.73)
P = 0.014IPTW
0.27(0.15–0.47)
P < 0.001Observational data: associations, not effects.
Further findings
Hospital LOS
P = 0.045
Safety
Severe complications (Clavien-Dindo III-IV)
P = 0.01
Original publication
Prevention of Liver-related Surgical Site Infections in Combined Liver and Colorectal Surgery. Ann Surg. Published 3 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →