Respiratory failure & ventilation
Individual response in patient’s effort and driving pressure to variations in assistance during pressure support ventilation
Authors' conclusion
Patients react to a decrease in PSV by increasing inspiratory effort-as estimated by PMI-keeping Vt and ∆P on a desired value, therefore, limiting the clinician's ability to modulate them.
Study context
- Population
- Patients recovering from acute respiratory failure ventilated by Pressure Support Ventilation (PSV)
- Participants
- 18 patients
- Comparison
- PS +3 and +6 cmH2O above vs −3 and −6 cmH2O below clinically set PS
- + 6n = 18
- + 3n = 18
- Clinically set PSn = 18reference
- −3n = 18
- −6n = 18
- Primary endpoint
- Change in patient's effort (PMI), ∆P and Vt in response to variations in PSV; robustness of Crs measurement
Methodological detailscross-randomized, four steps of assistance
- Cross-randomized
- Four steps of assistance
Primary result
As reported in the abstract
Response to decreasing PSV
- Pplat decreased from 20.5 ± 3.3 cmH2O to 16.7 ± 2.9
- P < 0.001
- ∆P decreased from 12.5 ± 2.3 to 8.6 ± 2.3 cmH2O
- P < 0.001
- Peak airway pressure decreased from 21.7 ± 3.8 to 9.7 ± 3.8 cmH2O
- P < 0.001
- Pressure-muscle-index (PMI) correlated with diaphragm sEMG
- r = 0.614; P < 0.001
- Crs did not change through steps
- P = 0.119
Original publication
Individual response in patient’s effort and driving pressure to variations in assistance during pressure support ventilation. Ann Intensive Care. Published 20 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →