Cardiothoracic & vascular anesthesia
Individualized mean arterial pressure during cardiac surgery The OPTIPAM Randomized Clinical Trial
Primary result · Composite of all-cause death, acute kidney injury, or prespecified neurologic complicationsResult — go to the resultRelative risk 1.1 95% CI 0.7–1.8- stopped early by the data and safety monitoring board
Authors' conclusion
In patients undergoing cardiac surgery, it was not possible to determine whether an individualized MAP strategy reduced major postoperative complications. More bleeding complications were observed in the individualized group. Future studies should further investigate this safety signal when evaluating individualized blood pressure targets.
Study context
- Population
- Adult patients undergoing elective cardiac surgery with cardiopulmonary bypassenrolled before the trial was stopped early
- Participants
- 172 patients
- Comparison
- Individualized mean arterial pressure (MAP) management vs standard management
- Individualized groupn = 85
- Standard groupn = 87reference
- Primary endpoint
- Composite of:
- All-cause death
- Acute kidney injury
- Prespecified neurologic complications
- Follow-up
- Within 7 days
Methodological details10 tertiary centers in France
- 10 tertiary centers in France
Primary result
As reported in the abstract
Relative risk
1.1
95% CI 0.7–1.8
P = 0.76
Events by treatment group
Individualized groupvs standard group
relative risk 1.1 (95% CI 0.7–1.8); P = 0.76
Further findings
Mean intraoperative MAP
- Mean intraoperative MAP — Target adherence, individualized group (% of intraoperative time)
- 33%
- Mean intraoperative MAP: P<0.001
Mean intraoperative MAP
- Greater vasopressor use with individualized management
Conduct of the study
- Trial stopped early by the data and safety monitoring board because of increased bleeding in the individualized group
Safety
Hemorrhagic complications
- Hemorrhagic complications: P=0.003
Original publication
Individualized mean arterial pressure during cardiac surgery The OPTIPAM Randomized Clinical Trial. Anesthesiology. Published 6 November 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →