Perioperative medicine & outcomes
Indole-3-Propionic Acid, a Gut Microbiota Metabolite, Protects Against the Development of Postoperative Delirium
Authors' conclusion
Gut microbiota-derived IPA is an important molecule implicated in the pathogenesis of POD, which could potentially be harnessed for POD prevention.
Study context
- Population
- Older patients undergoing anesthesia/surgery; preclinical mouse models of postoperative delirium (POD)17 POD cases
- Participants
- 103 patients
- Outcome
- POD development associated with preoperative gut microbiota metabolites
Methodological detailsmetabolomics (liquid chromatography with tandem mass spectrometry), chemogenetics
- Metabolomics (liquid chromatography with tandem mass spectrometry)
- Chemogenetics
Main finding
As reported in the abstract
Baseline plasma IPA and POD
- Baseline plasma IPA levels significantly inversely correlated with onset of POD
Observational data: associations, not effects.
Further findings
Mouse models of POD
- Reducing IPA via gut microbiota perturbation promoted POD-like behavior
- IPA administration deterred POD-like behavior
- Colonization of germ-free mice with mutant Clostridium sporogenes not producing IPA promoted POD-like behavior
- Protective effect of IPA mediated in part by PGC-1α in hippocampal interneurons
Original publication
Indole-3-Propionic Acid, a Gut Microbiota Metabolite, Protects Against the Development of Postoperative Delirium. Ann Surg. Published 27 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →