Decision Support Tools for Adjusting Perioperative Opioid Dosing as Individualised Postoperative Pain Management: A Systematic Review
Authors' conclusion
No prediction model study provided concrete guidance for individualising systemic opioid treatment. Nociception monitor-guided opioid doses did not improve acute postoperative pain, opioid use or opioid-related adverse events.
Study context
- Population
- Adult surgical patients; perioperative systemic opioid dosing as individualised postoperative pain management19 studies
- Comparison
- Decision support tools (prediction models or nociception monitoring systems) for adjusting perioperative systemic opioid dosing
- Outcome
- Effects of decision support tools on postoperative outcomes:
- Pain
- Opioid use
- Opioid-related adverse events
- Follow-up
- Within 24 h
Methodological detailsmeta-analyses of RCTs only (intervention studies), Searched EMBASE, MEDLINE and Cochrane Library up to August 2025, Risk of bias: PROBAST (prediction models); Cochrane Risk of Bias and ROBINS-I (intervention studies)
- Meta-analyses of RCTs only (intervention studies)
- Searched EMBASE, MEDLINE and Cochrane Library up to August 2025
- Risk of bias: PROBAST (prediction models); Cochrane Risk of Bias and ROBINS-I (intervention studies)
Pooled result
As reported in the abstract
within 24 h after surgery
| Group | R2 range |
|---|---|
| Prediction models | 0.100-0.313 |
Prediction models
R2 range0.100-0.313
Safety
Opioid-related adverse events (nociception monitoring systems) · within 24 h after surgery
- No significant effect
Original publication
Decision Support Tools for Adjusting Perioperative Opioid Dosing as Individualised Postoperative Pain Management: A Systematic Review. Acta Anaesthesiol Scand. Published 11 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →