Perioperative medicine & outcomes
Influence of Neostigmine on Early Postoperative Cognitive Dysfunction in Older Adult Patients Undergoing Noncardiac Surgery: A Double-Blind, Placebo-Controlled, Randomized Controlled Trial
Primary result · Incidence of POCDResult — go to the resultDifference −22% 95% CI −37 to −7Authors' conclusion
Neostigmine reduced POCD on the first day after noncardiac surgery in older patients. Neostigmine treatment inhibited oxidative stress and increased serum BDNF levels. There was no significant influence of neostigmine on POCD on the third or seventh day after surgery.
Study context
- Population
- Elderly patients (≥65 years) undergoing noncardiac surgery
- Participants
- 118 patients
- Comparison
- Neostigmine vs placebo postoperatively
- Primary endpoint
- Incidence of postoperative cognitive dysfunction (POCD) (Z-scores for mini-mental state examination and Montreal Cognitive Assessment both ≤−1.96)
Methodological detailsdouble-blind, placebo-controlled
- Double-blind
- Placebo-controlled
Primary result
Incidence of POCD · First day after surgery
Difference
−22%
95% CI −37 to −7
Neostigmine vs Placebo
difference −22% (95% CI −37 to −7)
As reported in the abstract
Further findings
| Outcome | Difference (95% CI) | |
|---|---|---|
| Incidence of POCD · Third day after surgery | 8% (−4 to 20) | |
| Incidence of POCD · Seventh day after surgery | 3% (−7 to 13) | |
| −100102030Difference (linear scale) |
| Outcome | P value |
|---|---|
| Plasma MDA levels · First day after surgerySignificantly lower with neostigmine | P = 0.016 |
| Serum SOD levels · First day after surgeryIncreased with neostigmine | P = 0.036 |
| Serum BDNF levels · First day after surgeryIncreased with neostigmine | .013 |
Original publication
Influence of Neostigmine on Early Postoperative Cognitive Dysfunction in Older Adult Patients Undergoing Noncardiac Surgery: A Double-Blind, Placebo-Controlled, Randomized Controlled Trial. Anesth Analg. Published 16 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →