Influence of nitrous oxide added to general anaesthesia on postoperative mortality and morbidity: a systematic review and meta-analysis
Authors' conclusion
N2O did not influence postoperative mortality or most morbidity outcomes.
Study context
- Population
- Patients undergoing GA
- Participants
- 22,147 patients · 71 RCTs
- Comparison
- GA with vs without nitrous oxide (N2O)
- Outcome
- Mortality and organ-related morbidity
Methodological detailsrandom-effects model, StEP outcome set
- Random-effects model
- StEP outcome set
Pooled result
As reported in the abstract
Postoperative mortality and organ-related morbidity
Atelectasis increased with N2O
RR 1.62 1.62
95% CI 1.24 to 2.12
Further pooled results
| Outcome | SMD (95% CI) | |
|---|---|---|
| Intraoperative opioid consumption | −0.19 (−0.35 to −0.04) | |
| −0.4−0.200.2Difference (linear scale) |
| Outcome | MD (min) (95% CI) | |
|---|---|---|
| Time to extubation | −2.17 (−3.32 to −1.03) | |
| −4−202Difference, min (linear scale) |
Safety
| Outcome | RR (95% CI) | |
|---|---|---|
| Atelectasis | 1.62 (1.24–2.12) | |
| PONV | 1.27 (1.15–1.40) | |
| 0.512Relative risk (log scale) |
Original publication
Influence of nitrous oxide added to general anaesthesia on postoperative mortality and morbidity: a systematic review and meta-analysis. Br J Anaesth. Published 11 March 2024. doi:10.
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