Influence of portal hypertension-associated upper gastrointestinal bleeding and acute kidney injury on liver transplantation prognosis
Authors' conclusion
Patients who experience preoperative GIB face an elevated risk of developing AKI, which is significantly correlated with a poorer prognosis for LT.
Study context
- Population
- Liver transplantation (LT) recipients with no evidence of acute kidney injury (AKI) or chronic kidney disease 2 months before LTretrospective cohort
- Participants
- 581 recipients
- Comparison
- Preoperative gastrointestinal bleeding (GIB) vs no preoperative GIB before LT
- GIB(+)n = 134
- GIB(-)n = 246reference
- Outcome
- Preoperative AKI
Methodological detailsmatched, subgroup analysis by preoperative AKI
- Matched
- Subgroup analysis by preoperative AKI
Main finding
As reported in the abstract
P = 0.039
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| 5-year survival, GIB(+) AKI(+) vs GIB(+) AKI(-) (subgroup) | P = 0.040 |
- 5-year survival, GIB(+) AKI(+) vs GIB(+) AKI(-) (subgroup): GIB(+) AKI(+) 65.0%
- 5-year survival, GIB(+) AKI(+) vs GIB(+) AKI(-) (subgroup): GIB(+) AKI(-) 82.5%
Postoperative complications, hospital stay, long-term survival
- Higher postoperative complication rates and prolonged hospital stay in GIB(+); long-term survival similar between groups
Postoperative AKI and 60-day mortality, GIB(+) AKI(+) vs GIB(+) AKI(-) (subgroup)
- Elevated in GIB(+) AKI(+) vs GIB(+) AKI(-)
GIB(+) vs GIB(-) within AKI(+) and within AKI(-) (subgroup)
- No significant difference in postoperative complications, short-term mortality, and long-term survival
Original publication
Influence of portal hypertension-associated upper gastrointestinal bleeding and acute kidney injury on liver transplantation prognosis. Perioper Med (Lond). Published 3 June 2025. doi:10.
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