Influence of semaglutide use on the presence of residual gastric solids on gastric ultrasound: a prospective observational study in volunteers without obesity recently started on semaglutide
Main finding · Solids on gastric ultrasound, supine positionResult — go to the resultRelative risk 3.50 95% CI 1.26–9.65Authors' conclusion
This study provides preliminary evidence that GLP-1RAs may affect gastric emptying and residual gastric contents following an overnight fast and two hours after clear liquids, which may have implications for aspiration risk during anesthetic care.
Study context
- Population
- Adult volunteers without obesity recently started on semaglutide, and controls
- Participants
- 20 volunteers
- Exposure
- Semaglutide users vs controls
- Semaglutiden = 10
- Controln = 10reference
- Outcome
- Solid gastric contents on gastric ultrasound (supine and lateral positions)
- Follow-up
- After an eight-hour fast
Main finding
Solids on gastric ultrasound, supine position · after eight-hour fast
Relative risk
3.50
95% CI 1.26–9.65
P = 0.02
By group
Semaglutide vs Control
RR 3.50 (95% CI 1.26–9.65); P = 0.02
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Semaglutide | Control | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| Solids on gastric ultrasound, lateral position · after eight-hour fast | 90% | 20% | 7.36 (1.13–47.7) | P = 0.005 | |
| 0.050.21520Relative risk (log scale) |
Stomach rated empty, supine position · 2 h after drinking 12 fluid ounces of water
P = 0.02
Gastric contents, lateral position · 2 h after clear liquids
- The two groups did not differ
Original publication
Influence of semaglutide use on the presence of residual gastric solids on gastric ultrasound: a prospective observational study in volunteers without obesity recently started on semaglutide. Can J Anaesth. Published 19 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →