Inhaled antibiotics for treating pneumonia in invasively ventilated patients in intensive care unit: a meta-analysis of randomized clinical trials with trial sequential analysis
Pooled result · Low certainty of evidenceResult — go to the resultOdds ratio 2.63 95% CI 1.36–5.09Authors' conclusion
In conclusion, compared to the sole intravenous therapy, the use of adjuvant inhaled antibiotics for treatment of pneumonia in invasively ventilated critically ill patients was associated with a greater incidence of microbiological eradication (low GRADE and high risk of publication bias), but not with clinical recovery and survival.
Study context
- Population
- Invasively ventilated intensive care units (ICU) adults with pneumonia
- Participants
- 1,472 participants · 11 randomized clinical trials (RCTs)
- Comparison
- Inhaled vs Control
- Outcome
- Rate of microbiological eradication after treatment
Methodological detailstrial sequential analysis, GRADE assessment
- Trial sequential analysis
- GRADE assessment
Pooled result
Low certainty of evidence
Odds ratio
2.63
95% CI 1.36–5.09
Inhaled vs Control
OR 2.63 (95% CI 1.36–5.09)
As reported in the abstract
Further pooled results
Clinical recovery, ICU and hospital survival (MDR pneumonia or not)
- Not different between groups
Safety
| Outcome | OR (95% CI) | |
|---|---|---|
| BronchospasmHigh evidence | 3.15 (1.33–7.47) | |
| 0.10.31310Odds ratio (log scale) |
Nephrotoxicity
- Not different between groups
Original publication
Inhaled antibiotics for treating pneumonia in invasively ventilated patients in intensive care unit: a meta-analysis of randomized clinical trials with trial sequential analysis. Crit Care. Published 25 November 2024. doi:10.
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