Prophylactic Antibiotics Delivered Via the Respiratory Tract to Reduce Ventilator-Associated Pneumonia: A Systematic Review, Network Meta-Analysis, and Trial Sequential Analysis of Randomized Controlled Trials
Pooled result · VAPResult — go to the resultRelative risk 0.69 95% CI 0.53–0.89Authors' conclusion
In adult patients with mechanical ventilation for over 48 h, prophylactic antibiotics delivered via the respiratory tract reduced the risk of VAP, particularly for those treated with nebulized aminoglycosides.
Study context
- Population
- Adults on mechanical ventilation for over 48 h
- Participants
- 1,445 adults · 7 RCTs
- Comparison
- Prophylactic antibiotics delivered via the respiratory tract vs control
- Outcome
- Ventilator-associated pneumonia (VAP)
Methodological detailsrandom-effects model, predefined subgroup analyses, GRADE certainty assessment, observational studies for sensitivity analyses, Results confirmed in sensitivity analyses
- Random-effects model
- Predefined subgroup analyses
- GRADE certainty assessment
- Observational studies for sensitivity analyses
- Results confirmed in sensitivity analyses
Pooled result
As reported in the abstract
Relative risk
0.69
95% CI 0.53–0.89
Respiratory-tract antibiotics vs Control
RR 0.69 (95% CI 0.53–0.89)
Further pooled results
| Outcome | RR (CI) | |
|---|---|---|
| VAP, aminoglycosides (subgroup) | 0.67 (0.47–0.97) | |
| VAP, nebulization (subgroup) | 0.64 (0.49–0.83) | |
| 0.512Relative risk (log scale) |
Mortality, MV duration, ICU and hospital LOS, systemic antibiotic duration, tracheostomy
- No significant differences between the two groups
Safety
Adverse events
- No significant difference between the two groups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Prophylactic Antibiotics Delivered Via the Respiratory Tract to Reduce Ventilator-Associated Pneumonia: A Systematic Review, Network Meta-Analysis, and Trial Sequential Analysis of Randomized Controlled Trials. Crit Care Med. Published 9 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →