Hemodynamics, fluids & transfusion
Integration of Right Ventricular Systolic and Diastolic Function With Invasive Cardiac Output: Association with Renal Replacement Therapy in Ischemic Cardiogenic Shock
Authors' conclusion
These results indicate that impaired RV systolic and diastolic functions are associated with RRT in AMI-CS patients.
Study context
- Population
- Patients with acute myocardial infarction complicated by cardiogenic shock (AMI-CS) in a tertiary cardiac ICU, London, UK
- Participants
- 43 patients
- Comparison
- Renal replacement therapy (RRT) vs no RRT
- RRTn = 14
Methodological detailssingle-centre (tertiary cardiac ICU)
- Single-centre (tertiary cardiac ICU)
Primary result
As reported in the abstract
Right ventricular (RV) S' (tricuspid annulus systolic velocity)
31% lower
P = 0.001
RRT
RV a' (late diastolic velocity)
19% lower
P = 0.007
RRT
Invasive native cardiac output (CO)
19% reduced
P = 0.03
RRT
Further findings
Association with RRT and discrimination
| OR | P value | |
|---|---|---|
| RV S'AUC = 0.80, cutoff 10.5 cm/s | 0.68 | P = 0.006 |
| RV a'AUC = 0.76, cutoff of 14 cm/s | 0.84 | P = 0.02 |
| Invasive native COAUC = 0.75, cutoff of 5 L/min | 0.47 | P = 0.02 |
- Association with RRT and discrimination — Combined RV S', RA a' and CO AUC
- 0.87
Incidence of RRT for AKI
- RRT required
- 33% (14/43)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Integration of Right Ventricular Systolic and Diastolic Function With Invasive Cardiac Output: Association with Renal Replacement Therapy in Ischemic Cardiogenic Shock. J Cardiothorac Vasc Anesth. Published 30 May 2025. doi:10.
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