Extracorporeal Membrane Oxygenation Complications Are Not Causal for Mortality in Patients With Infarct-Related Cardiogenic Shock: A Mediation Analysis of the Extracorporeal Life Support in Infarct-Related Cardiogenic Shock (ECLS-SHOCK) Trial
Authors' conclusion
VA-ECMO use in patients with AMI-CS was associated with increased frequencies of moderate to severe bleeding as well as vascular complications warranting intervention. However, these possible VA-ECMO-related complications did not mediate an increased mortality risk.
Study context
- Population
- Adults with acute myocardial infarction complicated by cardiogenic shock (AMI-CS), 44 centres
- Participants
- 417 adults
- Comparison
- Routine venoarterial extracorporeal membrane oxygenation (VA-ECMO) vs medical therapy
- Primary endpoint
- Rate of complications and mortality, and causes of death
- Follow-up
- 30 days
Methodological detailsmediation analysis, multicentre, international
- Mediation analysis
- Multicentre
- International
Primary result
As reported in the abstract
Mediation effect of possible VA-ECMO-related complications on 30-day mortality
- No significant mediation effect of possible VA-ECMO-related complications on 30-day mortality
- Logistic regression: no significant association between frequency of VA-ECMO-related complications and mortality
Further findings
Death with bleeding as primary cause · 30 days
- Patients who died from bleeding as primary cause of death
- 4
Safety
Moderate or severe bleeding · 30 days
P < 0.001
Peripheral vascular complications requiring intervention · 30 days
p equals to 0.008
Possible VA-ECMO-related complications, all patients · 30 days
- Patients with possible VA-ECMO-related complications (mostly within 5 days of randomisation)
- 88 (21.1%)
Original publication
Extracorporeal Membrane Oxygenation Complications Are Not Causal for Mortality in Patients With Infarct-Related Cardiogenic Shock: A Mediation Analysis of the Extracorporeal Life Support in Infarct-Related Cardiogenic Shock (ECLS-SHOCK) Trial. Crit Care Med. Published 17 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →