Pediatric anesthesia & critical care
Intercostal Nerve Cryoablation Reduces Opioid Use and Length of Stay Without Increasing Adverse Events: A Retrospective Cohort Study of 5442 Patients Undergoing Surgical Correction of Pectus Excavatum
Main finding · Inpatient opioid use (total oral MME)Result — go to the resultMedian decrease 80.8 total oral morphine equivalents 95% CI 68.6–93.0Authors' conclusion
Introduction of cryoablation for perioperative analgesia was associated with decreased inpatient opioid use and length of stay in a large sample with no change in adverse events.
Study context
- Population
- Patients undergoing minimally invasive correction of pectus excavatum (MIRPE) at 44 children's hospitals, 2016–202244 children's hospitals
- Participants
- 5,442 patients
- Exposure
- MIRPE with vs without intercostal nerve cryoablation
- Cryoablationn = 1,592
- Outcome
- Inpatient opioid use (total oral MME)
Methodological detailsmulticentre database (Pediatric Health Information System), before-after initiation of cryoablation
- Multicentre database (Pediatric Health Information System)
- Before-after initiation of cryoablation
Main finding
As reported in the abstract
Median decrease
80.8 total oral morphine equivalents
95% CI 68.6–93.0
Observational data: associations, not effects.
Further findings
Estimated median LOS (risk-adjusted)
P value: 0.016
Safety
- Cryoablation not significantly associated with an increase in any studied adverse events
Original publication
Intercostal Nerve Cryoablation Reduces Opioid Use and Length of Stay Without Increasing Adverse Events: A Retrospective Cohort Study of 5442 Patients Undergoing Surgical Correction of Pectus Excavatum. Ann Surg. Published 4 October 2023. doi:10.
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