Neuroanesthesia & neurocritical care
Intestinal Drug Absorption After Subarachnoid Hemorrhage and Elective Neurosurgery: Insights From Esomeprazole Pharmacokinetics
Authors' conclusion
Following SAH, significantly reduced drug absorption may be attributed to decreased intestinal motility and compromised intestinal mucosal function.
Study context
- Population
- Patients with high-grade subarachnoid hemorrhage (SAH) and elective cranial surgery controls receiving esomeprazole (orally or via nasogastric tube), academic hospital in Germany
- Participants
- 17 vs 17
- Exposure
- High-grade SAH vs elective cranial surgery controls
- SAHn = 17
- Controlsn = 17reference
- Outcome
- Intestinal drug absorption (esomeprazole)
Methodological detailssingle-centre, Esomeprazole serum concentrations measured on days 1, 3 and 4 in both groups and day 7 in the SAH group
- Single-centre
- Esomeprazole serum concentrations measured on days 1, 3 and 4 in both groups and day 7 in the SAH group
Main finding
As reported in the abstract
- Severely impaired drug absorption in patients with high-grade SAH
Observational data: associations, not effects.
Further findings
Intestinal drug absorption, SAH group · a week after hemorrhage
- Most patients showed no improvement
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Intestinal Drug Absorption After Subarachnoid Hemorrhage and Elective Neurosurgery: Insights From Esomeprazole Pharmacokinetics. Crit Care Med. Published 20 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →